Ontology highlight
ABSTRACT:
SUBMITTER: Muranen TA
PROVIDER: S-EPMC7483417 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Muranen Taru A TA Khan Sofia S Fagerholm Rainer R Aittomäki Kristiina K Cunningham Julie M JM Dennis Joe J Leslie Goska G McGuffog Lesley L Parsons Michael T MT Simard Jacques J Slager Susan S Soucy Penny P Easton Douglas F DF Tischkowitz Marc M Spurdle Amanda B AB Schmutzler Rita K RK Wappenschmidt Barbara B Hahnen Eric E Hooning Maartje J MJ Singer Christian F CF Wagner Gabriel G Thomassen Mads M Pedersen Inge Sokilde IS Domchek Susan M SM Nathanson Katherine L KL Lazaro Conxi C Rossing Caroline Maria CM Andrulis Irene L IL Teixeira Manuel R MR James Paul P Garber Judy J Weitzel Jeffrey N JN Jakubowska Anna A Yannoukakos Drakoulis D John Esther M EM Southey Melissa C MC Schmidt Marjanka K MK Antoniou Antonis C AC Chenevix-Trench Georgia G Blomqvist Carl C Nevanlinna Heli H
NPJ breast cancer 20200910
Germline genetic variation has been suggested to influence the survival of breast cancer patients independently of tumor pathology. We have studied survival associations of genetic variants in two etiologically unique groups of breast cancer patients, the carriers of germline pathogenic variants in <i>BRCA1</i> or <i>BRCA2</i> genes. We found that rs57025206 was significantly associated with the overall survival, predicting higher mortality of <i>BRCA1</i> carrier patients with estrogen receptor ...[more]