Human T_H1 and T_H2 cells targeting rhinovirus and allergen coordinately promote allergic asthma.

ABSTRACT:

Background

Allergic asthmatic subjects are uniquely susceptible to acute wheezing episodes provoked by rhinovirus. However, the underlying immune mechanisms and interaction between rhinovirus and allergy remain enigmatic, and current paradigms are controversial.

Objective

We sought to perform a comprehensive analysis of type 1 and type 2 innate and adaptive responses in allergic asthmatic subjects infected with rhinovirus.

Methods

Circulating virus-specific T_H1 cells and allergen-specific T_H2 cells were precisely monitored before and after rhinovirus challenge in allergic asthmatic subjects (total IgE, 133-4692 IU/mL; n = 28) and healthy nonallergic controls (n = 12) using peptide/MHCII tetramers. T cells were sampled for up to 11 weeks to captur

SUBMITTER: Muehling LM 

PROVIDER: S-EPMC7483727 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature