Post-TBI splenectomy may exacerbate coagulopathy and platelet activation in a murine model.

ABSTRACT:

Introduction

Traumatic brain injury (TBI) induces acute hypocoagulability, subacute hypercoagulability, and persistently elevated risk for thromboembolic events. Splenectomy is associated with increased mortality in patients with moderate or severe TBI. We hypothesized that the adverse effects of splenectomy in TBI patients may be secondary to the exacerbation of pathologic coagulation and platelet activation changes.

Methods

An established murine weight-drop TBI model was utilized and a splenectomy was performed immediately following TBI. Sham as well as TBI and splenectomy alone mice were used as injury controls. Mice were sacrificed for blood draws at 1, 6, and 24 h, as well as 7 days post-TBI. Viscoelastic coagulation parameters were assessed by rotational thromboelastom

SUBMITTER: Morris MC 

PROVIDER: S-EPMC7484105 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature