Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC7484147 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wang Tina T Ma Jianzhu J Hogan Andrew N AN Fong Samson S Licon Katherine K Tsui Brian B Kreisberg Jason F JF Adams Peter D PD Carvunis Anne-Ruxandra AR Bannasch Danika L DL Ostrander Elaine A EA Ideker Trey T
Cell systems 20200702 2
All mammals progress through similar physiological stages throughout life, from early development to puberty, aging, and death. Yet, the extent to which this conserved physiology reflects underlying genomic events is unclear. Here, we map the common methylation changes experienced by mammalian genomes as they age, focusing on comparison of humans with dogs, an emerging model of aging. Using oligo-capture sequencing, we characterize methylomes of 104 Labrador retrievers spanning a 16-year age ran ...[more]