Progression of valvular calcification and risk of incident stroke: The Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Background and aims

Prevalent valvular calcification (VC) is associated with stroke but little is known about associations of VC progression with stroke.

Methods

Progression (interval increase >0 Agatston units/year) of aortic valvular calcification (AVC) and mitral annular calcification (MAC) was assessed by two cardiac CTs over a median of 2.4 years. We determined the risk of adjudicated total and ischemic stroke using Cox regression adjusted for cardiovascular disease (CVD) risk factors.

Results

We studied 5,539 MESA participants free of baseline CVD and atrial fibrillation. Baseline mean ± SD age was 62 ± 10 years; 53% were women; 83% had no progression of VC; 15%, progression at one site (AVC or MAC), and 3%, progression at both sites. Over a median of 12 years,

SUBMITTER: Fashanu OE 

PROVIDER: S-EPMC7484336 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature