GRK5 Controls SAP97-Dependent Cardiotoxic β₁ Adrenergic Receptor-CaMKII Signaling in Heart Failure.

ABSTRACT:

Rationale

Cardiotoxic β₁ adrenergic receptor (β₁AR)-CaMKII (calmodulin-dependent kinase II) signaling is a major and critical feature associated with development of heart failure. SAP97 (synapse-associated protein 97) is a multifunctional scaffold protein that binds directly to the C-terminus of β₁AR and organizes a receptor signalosome.

Objective

We aim to elucidate the dynamics of β₁AR-SAP97 signalosome and its potential role in chronic cardiotoxic β₁AR-CaMKII signaling that contributes to development of heart failure.

Methods and results

The integrity of cardiac β₁AR-SAP97 complex was examined in heart failure. Cardiac-specific deletion of SAP97 was developed to examine β₁AR signaling in a

SUBMITTER: Xu B 

PROVIDER: S-EPMC7484403 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature