Ontology highlight
ABSTRACT:
SUBMITTER: Lu AT
PROVIDER: S-EPMC7484780 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Lu Ake T AT Narayan Pritika P Grant Matthew J MJ Langfelder Peter P Wang Nan N Kwak Seung S Wilkinson Hilary H Chen Richard Z RZ Chen Jian J Simon Bawden C C Rudiger Skye R SR Ciosi Marc M Chatzi Afroditi A Maxwell Alastair A Hore Timothy A TA Aaronson Jeff J Rosinski Jim J Preiss Alicia A Vogt Thomas F TF Coppola Giovanni G Monckton Darren D Snell Russell G RG William Yang X X Horvath Steve S
Nature communications 20200910 1
Although Huntington's disease (HD) is a well studied Mendelian genetic disorder, less is known about its associated epigenetic changes. Here, we characterize DNA methylation levels in six different tissues from 3 species: a mouse huntingtin (Htt) gene knock-in model, a transgenic HTT sheep model, and humans. Our epigenome-wide association study (EWAS) of human blood reveals that HD mutation status is significantly (p < 10<sup>-7</sup>) associated with 33 CpG sites, including the HTT gene (p = 6. ...[more]