Dataset Information

Dose of Alcohol From Beer Required for Acute Reduction in Arterial Stiffness.

ABSTRACT: Acute beer or alcohol ingestion reduces arterial stiffness, but the dose required to reduce arterial stiffness is unclear. Therefore, this study aimed to determine the acute effects of ingesting various amounts of beer on arterial stiffness in healthy men. Nine men (20-22 years) participated, in eight trials in random order on different days. The participants each consumed 25, 50, 100, or 200 mL of alcohol-free beer (AFB25, AFB50, AFB100, and AFB200) or regular beer (B25, B50, B100, and B200), and were monitored for 60 min thereafter. Arterial stiffness did not significantly change among all AFB and B25. However, B50, B100, and B200 caused a significant decrease in arterial stiffness for approximately 30-60 min: heart-brachial pulse wave velocity (B50: -4.5 ± 2.4%; B100: -3.4 ± 1.3%; B200: -8.1 ± 2.6%); brachial-ankle pulse wave velocity (B50: -0.6 ± 2.0%; B100: -3.3 ± 1.1%; B200: -9.3 ± 3.0%); heart-ankle pulse wave velocity (B50: -3.7 ± 0.3%; B100: -3.3 ± 0.9%; B200: -8.1 ± 2.7%); and cardio-ankle vascular index (B50: -4.6 ± 1.3%; B100: -5.6 ± 0.8%; B200: -10.3 ± 3.1%). Positive control alcoholic beverages reduced arterial stiffness, and these reductions did not significantly differ regardless of the type of beverage. Our data show that consuming about 50 mL of beer can start to reduce arterial stiffness, and that the reduced arterial stiffness is mainly attributable to the alcohol in beer.

SUBMITTER: Nishiwaki M

PROVIDER: S-EPMC7485316 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Dose of Alcohol From Beer Required for Acute Reduction in Arterial Stiffness.

Nishiwaki Masato M Yamaguchi Takahiro T Nishida Ren R Matsumoto Naoyuki N

Frontiers in physiology 20200828

Acute beer or alcohol ingestion reduces arterial stiffness, but the dose required to reduce arterial stiffness is unclear. Therefore, this study aimed to determine the acute effects of ingesting various amounts of beer on arterial stiffness in healthy men. Nine men (20-22 years) participated, in eight trials in random order on different days. The participants each consumed 25, 50, 100, or 200 mL of alcohol-free beer (AFB25, AFB50, AFB100, and AFB200) or regular beer (B25, B50, B100, and B200), a ...[more]

PMID: 32982780

Similar Datasets

Project description:BackgroundChronic arterial stiffness contributes to the negative health effects of obesity and insulin resistance, which include hypertension, stroke, and increased cardiovascular and all-cause mortality. Weight loss and improved insulin sensitivity are individually associated with improved central arterial stiffness; however, their combined effects on arterial stiffness are poorly understood. The purpose of this study was to determine how insulin levels modify the improvements in arterial stiffness seen with weight loss in overweight and obese young adults.MethodsTo assess the effects of weight loss and decreased fasting insulin on vascular stiffness, we studied 339 participants in the Slow the Adverse Effects of Vascular Aging (SAVE) trial. At study entry, the participants were aged 20-45, normotensive, non-diabetic, and had a body-mass index of 25-39.9 kg/m2. Measures of pulse wave velocity (PWV) in the central (carotid-femoral (cfPWV)), peripheral (femoral-ankle (faPWV)), and mixed (brachial-ankle (baPWV)) vascular beds were collected at baseline and 6 months. The effects of 6-month change in weight and insulin on measures of PWV were estimated using multivariate regression.ResultsAfter adjustment for baseline risk factors and change in systolic blood pressure, 6-month weight loss and 6-month change in fasting insulin independently predicted improvement in baPWV but not faPWV or cfPWV. There was a significant interaction between 6-month weight change and change in fasting insulin when predicting changes in baPWV (p < 0.001). Individuals experiencing both weight loss and insulin reductions showed the greatest improvement in baPWV.ConclusionsYoung adults with excess weight who both lower their insulin levels and lose weight see the greatest improvement in vascular stiffness. This improvement in vascular stiffness with weight loss and insulin declines may occur throughout the vasculature and may not be limited to individual vascular beds.

Dataset Information

Dose of Alcohol From Beer Required for Acute Reduction in Arterial Stiffness.

Publications

Dose of Alcohol From Beer Required for Acute Reduction in Arterial Stiffness.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets