Purinergic System Signaling in Metainflammation-Associated Osteoarthritis.
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ABSTRACT:
SUBMITTER: Gratal P
PROVIDER: S-EPMC7485330 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Purinergic System Signaling in Metainflammation-Associated Osteoarthritis.
Gratal Paula P Lamuedra Ana A Medina Juan Pablo JP Bermejo-Álvarez Ismael I Largo Raquel R Herrero-Beaumont Gabriel G Mediero Aránzazu A
Frontiers in medicine 20200828
Inflammation triggered by metabolic imbalance, also called metainflammation, is low-grade inflammation caused by the components involved in metabolic syndrome (MetS), including central obesity and impaired glucose tolerance. This phenomenon is mainly due to excess nutrients and energy, and it contributes to the pathogenesis of osteoarthritis (OA). OA is characterized by the progressive degeneration of articular cartilage, which suffers erosion and progressively becomes thinner. Purinergic signal ...[more]
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