Ontology highlight
ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC7485722 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Zheng Xiangru X Wei Jinlai J Li Wenjun W Li Xiaoli X Wang Wuyi W Guo Jinbao J Fu Zhongxue Z
Aging 20200720 16
Colorectal cancer (CRC) is a prevalent worldwide disease in which the antioxidant enzyme peroxiredoxin 2 (PRDX2) plays an important role. To investigate the molecular mechanism of PRDX2 in CRC, we performed bioinformatics analysis of The Cancer Genome Atlas (TCGA) datasets and Gene Expression Omnibus (GEO) DataSets (accession no. <i>GSE81429</i>). Our results suggest that PRDX2 is associated with cell-cycle progression and autophagy activated by the P38 MAPK/FOXO signaling pathway. Using a short ...[more]