Dataset Information

Cognition and motor function: The gait and cognition pooled index.

ABSTRACT:

Background

There is a need for outcome measures with improved responsiveness to changes in pre-dementia populations. Both cognitive and motor function play important roles in neurodegeneration; motor function decline is detectable at early stages of cognitive decline. This proof of principle study used a Pooled Index approach to evaluate improved responsiveness of the predominant outcome measure (ADAS-Cog: Alzheimer's Disease Assessment Scale-Cognitive Subscale) when assessment of motor function is added.

Methods

Candidate Pooled Index variables were selected based on theoretical importance and pairwise correlation coefficients. Kruskal-Wallis and Mann-Whitney U tests assessed baseline discrimination. Standardized response means assessed responsiveness to longitudinal change.

Results

Final selected variables for the Pooled Index include gait velocity, dual-task cost of gait velocity, and an ADAS-Cog-Proxy (statistical approximation of the ADAS-Cog using similar cognitive tests). The Pooled Index and ADAS-Cog-Proxy scores had similar ability to discriminate between pre-dementia syndromes. The Pooled Index demonstrated trends of similar or greater responsiveness to longitudinal decline than ADAS-Cog-Proxy scores.

Conclusion

Adding motor function assessments to the ADAS-Cog may improve responsiveness in pre-dementia populations.

SUBMITTER: Kueper JK

PROVIDER: S-EPMC7485843 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Cognition and motor function: The gait and cognition pooled index.

Kueper Jacqueline K JK Lizotte Daniel J DJ Montero-Odasso Manuel M Speechley Mark M

PloS one 20200911 9

<h4>Background</h4>There is a need for outcome measures with improved responsiveness to changes in pre-dementia populations. Both cognitive and motor function play important roles in neurodegeneration; motor function decline is detectable at early stages of cognitive decline. This proof of principle study used a Pooled Index approach to evaluate improved responsiveness of the predominant outcome measure (ADAS-Cog: Alzheimer's Disease Assessment Scale-Cognitive Subscale) when assessment of motor ...[more]

PMID: 32915845

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Dataset Information

Cognition and motor function: The gait and cognition pooled index.

Background

Methods

Results

Conclusion

Publications

Cognition and motor function: The gait and cognition pooled index.

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