Ontology highlight
ABSTRACT:
SUBMITTER: Kim C
PROVIDER: S-EPMC7486119 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Kim Chiho C Wang Xu-Dong XD Yu Yonghao Y
eLife 20200826
It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various <i>BRCA</i>-mutated tumors. PARPi possess both PARP1 inhibition and PARP1 trapping activities. The relative contribution of these two mechanisms toward PARPi-induced innate immune signaling, however, is poorly understood. We find that the presence of the PARP1 protein with uncompromised DNA-binding activities is required for PARPi-induced innate immun ...[more]