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Molecular phylogeny and missense mutations of envelope proteins across coronaviruses.


ABSTRACT: Envelope (E) protein is one of the structural viroporins (76-109 amino acids) present in the coronavirus. Sixteen sequentially different E-proteins were observed from a total of 4917 available complete genomes as on 18th June 2020 in the NCBI database. The missense mutations over the envelope protein across various coronaviruses of the ?-genus were analyzed to know the immediate parental origin of the envelope protein of SARS-CoV2. The evolutionary origin is also endorsed by the phylogenetic analysis of the envelope proteins comparing sequence homology as well as amino acid conservations.

SUBMITTER: Hassan SS 

PROVIDER: S-EPMC7486180 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Molecular phylogeny and missense mutations at envelope proteins across coronaviruses.

Hassan Sk Sarif SS   Choudhury Pabitra Pal PP   Roy Bidyut B  

Genomics 20200912 6


Envelope (E) protein is one of the structural viroporins (76-109 amino acids long) present in the coronavirus. Sixteen sequentially different E-proteins were observed from a total of 4917 available complete SARS-CoV-2 genomes as on 18th June 2020 in the NCBI database. The missense mutations over the envelope protein across various coronaviruses of the β-genus were analyzed to know the immediate parental origin of the envelope protein of SARS-CoV-2. The evolutionary origin is also endorsed by the  ...[more]

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