Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC7486200 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Chen Jing J Zhou Qiong Q Liu Man-Hua MH Yang Yun-Sheng YS Wang Yin-Qi YQ Huang Ying Y Chen Guo-Qiang GQ
Stem cell reports 20200806 3
FAM122A is a highly conserved housekeeping gene, but its physiological and pathophysiological roles remain greatly elusive. Based on the fact that FAM122A is highly expressed in human CD71<sup>+</sup> early erythroid cells, herein we report that FAM122A is downregulated during erythroid differentiation, while its overexpression significantly inhibits erythrocytic differentiation in primary human hematopoietic progenitor cells and erythroleukemia cells. Mechanistically, FAM122A directly interacts ...[more]