Ontology highlight
ABSTRACT:
SUBMITTER: Bocchio M
PROVIDER: S-EPMC7486410 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Bocchio Marco M Gouny Claire C Angulo-Garcia David D Toulat Tom T Tressard Thomas T Quiroli Eleonora E Baude Agnès A Cossart Rosa R
Nature communications 20200911 1
The temporal embryonic origins of cortical GABA neurons are critical for their specialization. In the neonatal hippocampus, GABA cells born the earliest (ebGABAs) operate as 'hubs' by orchestrating population synchrony. However, their adult fate remains largely unknown. To fill this gap, we have examined CA1 ebGABAs using a combination of electrophysiology, neurochemical analysis, optogenetic connectivity mapping as well as ex vivo and in vivo calcium imaging. We show that CA1 ebGABAs not only o ...[more]