Ontology highlight
ABSTRACT:
SUBMITTER: Singh V
PROVIDER: S-EPMC7486443 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Singh Vibha V Bhoir Siddhant S Chikhale Rupesh V RV Hussain Javeena J Dwyer Donard D Bryce Richard A RA Kirubakaran Sivapriya S De Benedetti Arrigo A
iScience 20200820 9
Through <i>in vitro</i> kinase assays and docking studies, we report the synthesis and biological evaluation of a phenothiazine analog J54 with potent TLK1 inhibitory activity for prostate cancer (PCa) therapy. Most PCa deaths result from progressive failure in standard androgen deprivation therapy (ADT), leading to metastatic castration-resistant PCa. Treatments that can suppress the conversion to mCRPC have high potential to be rapidly implemented in the clinics. ADT results in increased expre ...[more]