Ontology highlight
ABSTRACT:
SUBMITTER: Gioeli D
PROVIDER: S-EPMC7486791 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Gioeli Daniel D Snow Chelsi J CJ Simmers Michael B MB Hoang Stephen A SA Figler Robert A RA Allende J Ashe JA Roller Devin G DG Parsons J Thomas JT Wulfkuhle Julia D JD Petricoin Emanuel F EF Bauer Todd W TW Wamhoff Brian R BR
Lab on a chip 20190301 7
The development of drugs to treat cancer is hampered by the inefficiency of translating pre-clinical in vitro monoculture and mouse studies into clinical benefit. There is a critical need to improve the accuracy of evaluating pre-clinical drug efficacy through the development of more physiologically relevant models. In this study, a human triculture 3D in vitro tumor microenvironment system (TMES) was engineered to accurately mimic the tumor microenvironment. The TMES recapitulates tumor hemodyn ...[more]