Ontology highlight
ABSTRACT:
SUBMITTER: Melin E
PROVIDER: S-EPMC7486888 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Melin Erik E Eide Per Kristian PK Ringstad Geir G
Scientific reports 20200911 1
Extra-vascular molecular clearance routes from the brain and cerebrospinal fluid (CSF) remain insufficiently characterized in humans. Animal studies consistently suggest that the cribriform plate and nasal lymphatic vessels are crucial for molecular clearance from CSF. In this study, we aimed to examine human in vivo transport of a CSF tracer from CSF to nasal mucosa. We hypothesised a CSF tracer would enrich in nasal mucosa provided that nasal lymphatic drainage has a significant role in CSF mo ...[more]