Ontology highlight
ABSTRACT:
SUBMITTER: Zuliani G
PROVIDER: S-EPMC7486910 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20200911 1
Late onset Alzheimer disease (LOAD) is traditionally considered as a separate disease from vascular dementia (VAD). However, growing evidence suggests that β-amyloid (Aβ) accumulation, that initiates LOAD-related neurodegeneration, is preceded by vascular events. Previous in vitro studies showed that β-secretase 1 (BACE1), the key-enzyme of amyloidogenesis, is upregulated by cerebrovascular insult; moreover, its activity is increased both in brain and serum of LOAD patients. We aimed to investig ...[more]