Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Zuliani G
PROVIDER: S-EPMC7486910 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease.
Zuliani Giovanni G Trentini Alessandro A Rosta Valentina V Guerrini Remo R Pacifico Salvatore S Bonazzi Stefania S Guiotto Anna A Passaro Angelina A Seripa Davide D Valacchi Giuseppe G Cervellati Carlo C
Scientific reports 20200911 1
Late onset Alzheimer disease (LOAD) is traditionally considered as a separate disease from vascular dementia (VAD). However, growing evidence suggests that β-amyloid (Aβ) accumulation, that initiates LOAD-related neurodegeneration, is preceded by vascular events. Previous in vitro studies showed that β-secretase 1 (BACE1), the key-enzyme of amyloidogenesis, is upregulated by cerebrovascular insult; moreover, its activity is increased both in brain and serum of LOAD patients. We aimed to investig ...[more]
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