Bcl6 and Blimp1 reciprocally regulate ST2⁺ Treg-cell development in the context of allergic airway inflammation.

ABSTRACT:

Background

Bcl6 is required for the development of T follicular helper cells and T follicular regulatory (Tfr) cells that regulate germinal center responses. Bcl6 also affects the function of regulatory T (Treg) cells.

Objective

The goal of this study was to define the functions of Bcl6 in Treg cells, including Tfr cells, in the context of allergic airway inflammation.

Methods

We used a model of house dust mite sensitization to challenge wild-type, Bcl6^fl/fl Foxp3-Cre, and Prdm1 (Blimp1)^fl/fl Foxp3-Cre mice to study the reciprocal roles of Bcl6 and Blimp1 in allergic airway inflammation.

Results

In the house dust mite model, Tfr cells repress the production of IgE and Bcl6⁺ Treg cells suppress the generation of type 2 cytokine-p

SUBMITTER: Koh B 

PROVIDER: S-EPMC7487006 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature