Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers.

ABSTRACT: BACKGROUND:Cold acclimation and exercise training were previously shown to increase peripheral insulin sensitivity in human volunteers with type 2 diabetes. Although cold is a potent activator of brown adipose tissue, the increase in peripheral insulin sensitivity by cold is largely mediated by events occurring in skeletal muscle and at least partly involves GLUT4 translocation, as is also observed for exercise training. METHODS:To investigate if cold acclimation and exercise training overlap in the molecular adaptive response in skeletal muscle, we performed transcriptomics analysis on vastus lateralis muscle collected from human subjects before and after 10?days of cold acclimation, as well as before and after a 12-week exercise training intervention. RESULTS:Cold acclimation altered the expression of 756 genes (422 up, 334 down, P?

SUBMITTER: Nascimento EBM 

PROVIDER: S-EPMC7487556 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature