Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy.

ABSTRACT: BACKGROUND:To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy. METHODS:The retrospective study included 7073 women with breast cancer without post-mastectomy radiotherapy: 4604 (65.1%) had pT1-2?N0 disease (low risk); 2042 (28.9%), pT1-2?N1 (intermediate risk); and 427 (6.0%), pT3-4 and/or pN2-3, or pT1-2?N1 after neoadjuvant chemotherapy (high risk). The distribution of cumulative locoregional recurrence was analyzed. The local recurrence and regional recurrence rates were estimated by the Kaplan-Meier method, and differences were compared with the log-rank test. Multivariate analysis was performed using Cox logistic regression analysis. RESULTS:In the median follow-up of 63.0?months, 469 patients had locoregional recurrence: chest wall recurrence in 238 (50.7%) cases, supraclavicular/infraclavicular nodes in 236 (50.3%) cases, axilla in 92 (19.6%), and internal mammary nodes in 50 (10.7%) cases. The 5-year local recurrence and regional recurrence rates were 2.5 and 4.4%, respectively. Subgroup analysis of the three risk groups and five molecular subtypes (luminal A, luminal B-Her2 negative, luminal B-Her2 positive, Her2-enriched, and triple negative) also showed that the chest wall and supraclavicular/infraclavicular nodes were the most common recurrence sites. Age, tumor location, T stage, N stage, and hormone receptor status were independent prognostic factors for both local recurrence and regional recurrence (p?

SUBMITTER: Zhao X 

PROVIDER: S-EPMC7487762 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature