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Childhood Langerhans cell histiocytosis with severe lung involvement: a nationwide cohort study.


ABSTRACT: BACKGROUND:Lung involvement in childhood Langerhans cell histiocytosis (LCH) is infrequent and rarely life threatening, but occasionally, severe presentations are observed. METHODS:Among 1482 children (

SUBMITTER: Le Louet S 

PROVIDER: S-EPMC7487928 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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<h4>Background</h4>Lung involvement in childhood Langerhans cell histiocytosis (LCH) is infrequent and rarely life threatening, but occasionally, severe presentations are observed.<h4>Methods</h4>Among 1482 children (< 15 years) registered in the French LCH registry (1994-2018), 111 (7.4%) had lung involvement. This retrospective study included data for 17 (1.1%) patients that required one or more intensive care unit (ICU) admissions for respiratory failure.<h4>Results</h4>The median age was 1.3  ...[more]

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