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Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.

ABSTRACT: Aim: Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). Patients & methods: One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls. Results: Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect: NPY1R/GAL rs4691910/rs1893679, NPY1R/GAL rs4691910/rs3136541 and GALR1/GAL rs9807208/rs3136541. Conclusion: This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.

SUBMITTER: Randesi M 

PROVIDER: S-EPMC7487975 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Further evidence for the association of <i>GAL</i>, <i>GALR1</i> and <i>NPY1R</i> variants with opioid dependence.

Randesi Matthew M   Levran Orna O   van den Brink Wim W   Blanken Peter P   van Ree Jan M JM   Ott Jurg J   Kreek Mary J MJ  

Pharmacogenomics 20200806 13

<b>Aim:</b> Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). <b>Patients & methods:</b> One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatme  ...[more]

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