Dataset Information

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology.

ABSTRACT: BACKGROUND:This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. METHODS:Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results. RESULTS:Of NILM cytology cases, the most frequent case was negative [LBC n?=?50 (90.9%), conventional n?=?22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBC n?=?34; 75.6%, conventional n?=?14; 70.0%). Among OHSIL cytodiagnoses (LBC n?=?51, conventional n?=?23), SCC was the most frequent (LBC n?=?31; 60.8%, conventional n?=?7; 30.4%). Negative cases were common (LBC n?=?13; 25.5%, conventional n?=?14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBC n?=?16; 88.9%, conventional n?=?14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%. CONCLUSIONS:LBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings.

SUBMITTER: Sukegawa S

PROVIDER: S-EPMC7488236 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology.

Sukegawa Shintaro S Ono Sawako S Nakano Keisuke K Takabatake Kiyofumi K Kawai Hotaka H Nagatsuka Hitoshi H Furuki Yoshihiko Y

Diagnostic pathology 20200910 1

<h4>Background</h4>This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods.<h4>Methods</h4>Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM ...[more]

PMID: 32912249

Similar Datasets

Project description:BackgroundWeifuchun (WFC), a Chinese herbal prescription consisting of Red Ginseng, Isodon amethystoides and Fructus Aurantii, is commonly used in China to treat a variety of chronic stomach disorders. The aim of the paper was to determine the effect of WFC on intestinal microbiota changes in precancerous lesions of gastric cancer (PLGC) patients.MethodsPLGC patients of H. pylori negative were randomly divided into two groups and received either WFC tablets for a dose of 1.44 g three times a day or vitacoenzyme (Vit) tablets for a dose of 0.8 g three times a day. All patients were treated for 6 months consecutively. Gastroscopy and histopathology were used to assess the histopathological changes in gastric tissues before and after treatment. 16S rRNA gene sequencing was carried out to assess the effects WFC on intestinal microbiota changes in PLGC patients. Receiver Operating Characteristics (ROC) analysis was used to assess the sensitivity and specificity of different intestinal microbiota in distinguishing between PLGC patients and healthy control group.ResultsGastroscopy and histopathological results indicated that WFC could improve the pathological condition of PLGC patients, especially in the case of atrophy or intestinal metaplasia. The results of 16S rRNA gene sequencing indicated that WFC could regulate microbial diversity, microbial composition, and abundance of the intestinal microbiota of PLGC patients. Following WFC treatment, the relative abundance of Parabacteroides decreased in WFC group when compared with the Vit group. ROC analysis found that the Parabacteroides could effectively distinguish PLGC patients from healthy individuals with sensitivity of 0.79 and specificity of 0.8.ConclusionsWFC could slow down the progression of PLGC by regulating intestinal microbiota abundance. Trial registration NCT03814629. Name of registry: Randomized Clinical Trial: Weifuchun Treatment on Precancerous Lesions of Gastric Cancer. Registered 3 August 2018-Retrospectively registered, https://register.clinicaltrials.gov/ NCT03814629.

Dataset Information

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology.

Publications

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets