Ontology highlight
ABSTRACT:
SUBMITTER: Fraczek K
PROVIDER: S-EPMC7488486 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Frączek Karolina K Ferraiolo Mattia M Hermans Emmanuel E Bujalska-Zadrozny Magdalena M Kasarello Kaja K Erdei Anna A Kulik Kamila K Kowalczyk Agnieszka A Wojciechowski Piotr P Sulejczak Dorota D Sosnowski Piotr P Granica Sebastian S Benyhe Sandor S Kaczynska Katarzyna K Nagraba Lukasz L Stolarczyk Artur A Cudnoch-Jedrzejewska Agnieszka A Kleczkowska Patrycja P
Acta pharmaceutica Sinica. B 20200501 8
The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose of 10 nmol/rat produced a potent pain-relieving effect, especially after its intrathecal administration. Compared with intrathecal morphine, this novel compound was found to possess a favourable side ...[more]