Ontology highlight
ABSTRACT:
SUBMITTER: Colomba A
PROVIDER: S-EPMC7489893 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Colomba Audrey A Fitzek Martina M George Roger R Weitsman Gregory G Roberts Selene S Zanetti-Domingues Laura L Hirsch Michael M Rolfe Daniel J DJ Mehmood Shahid S Madin Andrew A Claus Jeroen J Kjaer Svend S Snijders Ambrosius P AP Ng Tony T Martin-Fernandez Marisa M Smith David M DM Parker Peter J PJ
The Biochemical journal 20200901 17
Despite being catalytically defective, pseudokinases are typically essential players of cellular signalling, acting as allosteric regulators of their active counterparts. Deregulation of a growing number of pseudokinases has been linked to human diseases, making pseudokinases therapeutic targets of interest. Pseudokinases can be dynamic, adopting specific conformations critical for their allosteric function. Interfering with their allosteric role, with small molecules that would lock pseudokinas ...[more]