Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz-de-Angulo A
PROVIDER: S-EPMC7490994 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ruiz-de-Angulo Ane A Bilbao-Asensio Marc M Cronin James J Evans Stephen J SJ Clift Martin J D MJD Llop Jordi J Feiner Irene V J IVJ Beadman Rhiannon R Bascarán Kepa Zamacola KZ Mareque-Rivas Juan C JC
iScience 20200826 9
Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fenton chemistry. Here, we developed iron oxide-loaded nanovaccines (IONVs), which, chemically programmed to integrate iron catalysis, drug delivery, and tracking exploiting the characteristics of the t ...[more]