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Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients.

ABSTRACT: Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection.

SUBMITTER: Gama WM 

PROVIDER: S-EPMC7491275 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients.

Gama Wellington Mota WM   Oliveira Lucas Barbosa LB   Chaves Yury Oliveira YO   Ribeiro Flavio F   Almeida Taynná Vernalha Rocha TVR   Baptista Barbara Jose Antunes BJA   Santana Monique Freire MF   Ferreira Luis Carlos LC   Lacerda Marcus Vinicius Guimaraes MVG   Nogueira Paulo Afonso PA   Nogueira Paulo Afonso PA  

Memorias do Instituto Oswaldo Cruz 20200914

Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, whe  ...[more]

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