Ontology highlight
ABSTRACT:
SUBMITTER: Augsornworawat P
PROVIDER: S-EPMC7491368 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Augsornworawat Punn P Maxwell Kristina G KG Velazco-Cruz Leonardo L Millman Jeffrey R JR
Cell reports 20200801 8
Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet organoids could provide an unlimited cell source for diabetes cell replacement therapy. However, current SC-β cells generated in vitro are transcriptionally and functionally immature compared to native adult β cells. Here, we use single-cell transcriptomic profiling to catalog changes that occur in transplanted SC-β cells. We find that transplanted SC-β cells exhibit drastic transcriptional changes and ...[more]