Ontology highlight
ABSTRACT:
SUBMITTER: Dean NE
PROVIDER: S-EPMC7492005 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Dean Natalie E NE Pastore Y Piontti Ana A Madewell Zachary J ZJ Cummings Derek A T DAT Hitchings Matthew D T MDT Joshi Keya K Kahn Rebecca R Vespignani Alessandro A Halloran M Elizabeth ME Longini Ira M IM
Vaccine 20200915 46
To rapidly evaluate the safety and efficacy of COVID-19 vaccine candidates, prioritizing vaccine trial sites in areas with high expected disease incidence can speed endpoint accrual and shorten trial duration. Mathematical and statistical forecast models can inform the process of site selection, integrating available data sources and facilitating comparisons across locations. We recommend the use of ensemble forecast modeling - combining projections from independent modeling groups - to guide in ...[more]