Dataset Information

Using behavioral rhythms and multi-task learning to predict fine-grained symptoms of schizophrenia.

ABSTRACT: Schizophrenia is a severe and complex psychiatric disorder with heterogeneous and dynamic multi-dimensional symptoms. Behavioral rhythms, such as sleep rhythm, are usually disrupted in people with schizophrenia. As such, behavioral rhythm sensing with smartphones and machine learning can help better understand and predict their symptoms. Our goal is to predict fine-grained symptom changes with interpretable models. We computed rhythm-based features from 61 participants with 6,132 days of data and used multi-task learning to predict their ecological momentary assessment scores for 10 different symptom items. By taking into account both the similarities and differences between different participants and symptoms, our multi-task learning models perform statistically significantly better than the models trained with single-task learning for predicting patients' individual symptom trajectories, such as feeling depressed, social, and calm and hearing voices. We also found different subtypes for each of the symptoms by applying unsupervised clustering to the feature weights in the models. Taken together, compared to the features used in the previous studies, our rhythm features not only improved models' prediction accuracy but also provided better interpretability for how patients' behavioral rhythms and the rhythms of their environments influence their symptom conditions. This will enable both the patients and clinicians to monitor how these factors affect a patient's condition and how to mitigate the influence of these factors. As such, we envision that our solution allows early detection and early intervention before a patient's condition starts deteriorating without requiring extra effort from patients and clinicians.

SUBMITTER: Tseng VW

PROVIDER: S-EPMC7492221 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Using behavioral rhythms and multi-task learning to predict fine-grained symptoms of schizophrenia.

Tseng Vincent W-S VW Sano Akane A Ben-Zeev Dror D Brian Rachel R Campbell Andrew T AT Hauser Marta M Kane John M JM Scherer Emily A EA Wang Rui R Wang Weichen W Wen Hongyi H Choudhury Tanzeem T

Scientific reports 20200915 1

Schizophrenia is a severe and complex psychiatric disorder with heterogeneous and dynamic multi-dimensional symptoms. Behavioral rhythms, such as sleep rhythm, are usually disrupted in people with schizophrenia. As such, behavioral rhythm sensing with smartphones and machine learning can help better understand and predict their symptoms. Our goal is to predict fine-grained symptom changes with interpretable models. We computed rhythm-based features from 61 participants with 6,132 days of data an ...[more]

PMID: 32934246

Similar Datasets

Project description:BackgroundModels predicting future macrovascular invasion in hepatocellular carcinoma are constructed to assist timely interventions.MethodsA total of 366 HCC cases were retrospectively collected from five Chinese hospitals between April 2007 and November 2016: the training dataset comprised 281 patients from four hospitals; the external validation dataset comprised 85 patients from another hospital. Multi-task deep learning network-based models were constructed to predict future macrovascular invasion. The discrimination, calibration, and decision curves were compared to identify the best model. We compared the time to macrovascular invasion and overall survival using the best model and related image heterogeneity scores (H-score). Then, we determined the need for a segmentation subnet or the replacement deep learning algorithm by logistic regression in screening clinical/radiological factors. Finally, an applet was constructed for future application.FindingsThe best model combined clinical/radiological factors and radiomic features. It achieved best discrimination (areas under the curve: 0·877 in the training dataset and 0·836 in the validation dataset), calibration, and decision curve. Its performance was not affected by the treatments and disease stages. The subgroups had statistical significance for time to macrovascular invasion (training: hazard ratio [HR] = 0·073, 95% confidence interval [CI]: 0·032-0·167, p < 0·001 and validation: HR = 0·090, 95%CI: 0·022-0·366, p < 0·001) and overall survival (training: HR = 0·344, 95%CI: 0·246-0·547, p < 0·001 and validation: HR = 0·489, 95%CI: 0·279 - 0·859, p = 0·003). Similar results were achieved when the patients were subdivided by the H-score. The subnet for segmentation and end-to-end deep learning algorithms improved the performance of the model.InterpretationOur multi-task deep learning network-based model successfully predicted future macrovascular invasion. In high-risk populations, besides the current first-line treatments, more therapies may be explored for macrovascular invasion.

Project description:Since the inception of the current COVID-19 pandemic, related misleading information has spread at a remarkable rate on social media, leading to serious implications for individuals and societies. Although COVID-19 looks to be ending for most places after the sharp shock of Omicron, severe new variants can emerge and cause new waves, especially if the variants can evade the insufficient immunity provided by prior infection and incomplete vaccination. Fighting the fake news that promotes vaccine hesitancy, for instance, is crucial for the success of the global vaccination programs and thus achieving herd immunity. To combat the proliferation of COVID-19-related misinformation, considerable research efforts have been and are still being dedicated to building and sharing COVID-19 misinformation detection datasets and models for Arabic and other languages. However, most of these datasets provide binary (true/false) misinformation classifications. Besides, the few studies that support multi-class misinformation classification deal with a small set of misinformation classes or mix them with situational information classes. False news stories about COVID-19 are not equal; some tend to have more sinister effects than others (e.g., fake cures and false vaccine info). This suggests that identifying the sub-type of misinformation is critical for choosing the suitable action based on their level of seriousness, ranging from assigning warning labels to the susceptible post to removing the misleading post instantly. We develop comprehensive annotation guidelines in this work that define 19 fine-grained misinformation classes. Then, we release the first Arabic COVID-19-related misinformation dataset comprising about 6.7K tweets with multi-class and multi-label misinformation annotations. In addition, we release a version of the dataset to be the first Twitter Arabic dataset annotated exclusively with six different situational information classes. Identifying situational information (e.g., caution, help-seeking) helps authorities or individuals understand the situation during emergencies. To confirm the validity of the collected data, we define three classification tasks and experiment with various machine learning and transformer-based classifiers to offer baseline results for future research. The experimental results indicate the quality and validity of the data and its suitability for constructing misinformation and situational information classification models. The results also demonstrate the superiority of AraBERT-COV19, a transformer-based model pretrained on COVID-19-related tweets, with micro-averaged F-scores of 81.6% and 78.8% for the multi-class misinformation and situational information classification tasks, respectively. Label Powerset with linear SVC achieved the best performance among the presented methods for multi-label misinformation classification with micro-averaged F-scores of 76.69%.

Dataset Information

Using behavioral rhythms and multi-task learning to predict fine-grained symptoms of schizophrenia.

Publications

Using behavioral rhythms and multi-task learning to predict fine-grained symptoms of schizophrenia.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets