Dataset Information

Diabetes and mortality from respiratory diseases: the Japan Collaborative Cohort Study.

ABSTRACT: BACKGROUND:A little evidence was found about the association between diabetes and respiratory diseases mortality among Japanese populations. We aimed to explore the association between diabetes and the risk of respiratory diseases mortality through a nationwide prospective study in Japan. METHODS:95,056 participants (39,925 men and 55,131 women) were followed up for median 17.1 years. The information about diabetes status, sociodemographic characteristics, and lifestyles was collected at baseline. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) of mortality from respiratory diseases associated with baseline diabetes status. RESULTS:We identified 2,838 deaths from total respiratory diseases (1,759 respiratory infection, 432 chronic obstructive pulmonary disease, and 647 other respiratory diseases). The association between diabetes and total respiratory diseases mortality was statistically significant among women (HR=1.81, 95% CI, 1.39-2.37) but of borderline statistical significance in men (P for interaction<0.01). Besides, there were significant associations between diabetes and mortality from respiratory infection among both men and women (HR=1.39, 95% CI, 1.10-1.76; HR=2.30, 95% CI, 1.71-3.11; P for interaction<0.001). However, we failed to detect any statistically significant association between diabetes and COPD mortality. Moreover, the subgroup analysis revealed that the association between diabetes and total respiratory diseases mortality was stronger in never smokers when compared with ever smokers (P for interaction=0.02). CONCLUSIONS:Significant association was observed between diabetes and the risk of total respiratory diseases mortality in particular from respiratory infection. Prevention and control of respiratory diseases, especially respiratory infection should be paid more attention among people with diabetes in clinical and public health practice.

SUBMITTER: Wang M

PROVIDER: S-EPMC7492709 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Diabetes and Mortality From Respiratory Diseases: The Japan Collaborative Cohort Study.

Wang Mengying M Muraki Isao I Liu Keyang K Shirai Kokoro K Tamakoshi Akiko A Hu Yonghua Y Iso Hiroyasu H

Journal of epidemiology 20191214 10

<h4>Background</h4>Little evidence is available about the association between diabetes and respiratory disease mortality among Japanese populations. We aimed to explore the association between diabetes and the risk of respiratory diseases mortality through a nationwide prospective study in Japan.<h4>Methods</h4>We followed 95,056 participants (39,925 men and 55,131 women) for a median 17.1 years. The information about diabetes status, sociodemographic characteristics, and lifestyles was collecte ...[more]

PMID: 31839642

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Project description:BackgroundWhile women's parity status and education level have independent associations with cardiovascular and other diseases, no studies have evaluated the additive interaction of these two factors. Therefore, we examined the additive interaction between parity and education level on mortality from stroke, coronary heart disease, total cardiovascular disease, cancer, non-cardiovascular disease, and non-cancer causes, and all causes in Japanese women.MethodsThis study followed 41,242 women aged 40-79 years without a history of cardiovascular disease or cancer from 1988 to 1990 until 2009. Baseline parity and education level were classified into four categories, with highly educated parous women as the reference group. Cox proportional hazards regression analyses were performed to calculate the risk of mortality. We also assessed the additive interactions between parity and education level on mortality from cardiovascular disease and other causes using the relative excess risk due to interaction obtained using Cox models.ResultsDuring the median follow-up period of 19.1 years, we identified 6299 deaths. In a multivariable model adjusted for cardiovascular disease and other disease risk factors, nulliparous women with low education levels had increased multivariable-adjusted hazard ratios of 1.67 (95% confidence interval [CI] 1.13, 2.47) for stroke, 1.98 (95% CI 1.15, 3.39) for coronary heart disease, 1.71 (95% CI 1.34,2.18) for total cardiovascular disease, 1.69 (95% CI 1.33, 2.14) for non-cardiovascular and non-cancer, and 1.51 (95% CI 1.30, 1.75) for all-cause mortality when compared with highly educated parous women. Moreover, we observed significant additive interactions between parity and education level on total cardiovascular disease mortality (P = 0.04), non-cardiovascular disease and non-cancer mortality (P = 0.01), and all-cause mortality (P = 0.005).ConclusionsNulliparity and low education levels are super-additively associated with total cardiovascular disease, non-cardiovascular and non-cancer, and all-cause mortality risks, suggesting that nulliparous women with low education levels need specific support for preventing mortality related to cardiovascular and other diseases.

Dataset Information

Diabetes and mortality from respiratory diseases: the Japan Collaborative Cohort Study.

Publications

Diabetes and Mortality From Respiratory Diseases: The Japan Collaborative Cohort Study.

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