Ontology highlight
ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC7492993 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Chen Danqi D Chen Qiao Yi QY Wang Zhenjia Z Zhu Yusha Y Kluz Thomas T Tan Wuwei W Li Jinquan J Wu Feng F Fang Lei L Zhang Xiaoru X He Rongquan R Shen Steven S Sun Hong H Zang Chongzhi C Jin Chunyuan C Costa Max M
iScience 20200901 9
Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3' end. We previously demonstrated that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3.1 mRNA, causing transformation of human cells <i>in vitro</i>. Here we report that polyadenylation of H3.1 mRNA increases H3.1 protein, resulting in displacement of histone variant H3.3 at active promoters, enhancers, and insulator regions, leading to tra ...[more]