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The pharmacological development of direct acting agents for emerging needed therapy against severe acute respiratory syndrome coronavirus-2.


ABSTRACT: Recently, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was quickly identified as the causal pathogen leading to the outbreak of SARS-like illness all over the world. As the SARS-CoV-2 infection pandemic proceeds, many efforts are being dedicated to the development of diverse treatment strategies. Increasing evidence showed potential therapeutic agents directly acting against SARS-CoV-2 virus, such as interferon, RNA-dependent RNA polymerase inhibitors, protease inhibitors, viral entry blockers, neuraminidase inhibitor, vaccine, antibody agent targeting the SARS-CoV-2 RNA genome, natural killer cells, and nucleocytoplasmic trafficking inhibitor. To date, several direct anti-SARS-CoV-2 agents have demonstrated promising in vitro and clinical efficacy. This article reviews the current and future development of direct acting agents against SARS-CoV-2.

SUBMITTER: Wang SF 

PROVIDER: S-EPMC7493775 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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The pharmacological development of direct acting agents for emerging needed therapy against severe acute respiratory syndrome coronavirus-2.

Wang Sheng-Fan SF   Chen Kuan-Hsuan KH   Wang Szu-Yu SY   Yarmishyn Aliaksandr A AA   Lai Wei-Yi WY   Lin Yi-Ying YY   Wang Mong-Lien ML   Chou Shih-Jie SJ   Yang Yi-Ping YP   Chang Yuh-Lih YL  

Journal of the Chinese Medical Association : JCMA 20200801 8


Recently, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was quickly identified as the causal pathogen leading to the outbreak of SARS-like illness all over the world. As the SARS-CoV-2 infection pandemic proceeds, many efforts are being dedicated to the development of diverse treatment strategies. Increasing evidence showed potential therapeutic agents directly acting against SARS-CoV-2 virus, such as interferon, RNA-dependent RNA polymerase inhibitors, protease inhibitors, vi  ...[more]

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