Ontology highlight
ABSTRACT:
SUBMITTER: Kim MR
PROVIDER: S-EPMC7493981 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Kim Mi Ran MR Wu Meng-Ju MJ Zhang Yingsheng Y Yang Jer-Yen JY Chang Chun Ju CJ
Nature communications 20200915 1
Epigenetic regulation plays an important role in governing stem cell fate and tumorigenesis. Lost expression of a key DNA demethylation enzyme TET2 is associated with human cancers and has been linked to stem cell traits in vitro; however, whether and how TET2 regulates mammary stem cell fate and mammary tumorigenesis in vivo remains to be determined. Here, using our recently established mammary specific Tet2 deletion mouse model, the data reveals that TET2 plays a pivotal role in mammary gland ...[more]