Dataset Information

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.

ABSTRACT: A number of efforts are underway to better understand the role of genetic variation in successful aging and longevity. However, to date, only two genes have been consistently associated with longevity in humans: APOE and FOXO3, with the APOE ?2 allele also protective against dementia. Recently, using an exome-wide SNP array approach, a missense variant CLEC3B c.316G>A (rs13963 p.S106G) was reported to associate with longevity in two independent cohorts of Japanese and Chinese participants. Interestingly, CLEC3B p.S106G is more frequent in Caucasian populations. Herein, we examined the frequency of CLEC3B p.S106G in a Caucasian series of 1,483 neurologically healthy individuals with a specific subset >80 years of age. Although our findings do not support an association between CLEC3B p.S106G and aging without neurological disease (p = .89), we confirmed the association between the APOE ?2 allele and better survival without neurological disease (p = .001). Further assessment of healthy aged cohorts that retain intact neurological function will be critical to understand the etiology of neurodegenerative disease and the role of age at risk.

SUBMITTER: Kolicheski A

PROVIDER: S-EPMC7494029 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Publications

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.

Kolicheski Ana A Walton Ronald L RL Soto-Beasley Alexandra I AI Heckman Michael G MG Uitti Ryan J RJ Parfitt Francine F Graff-Radford Michelle R MR Wszolek Zbigniew K ZK Graff-Radford Neill R NR Ross Owen A OA

The journals of gerontology. Series A, Biological sciences and medical sciences 20200901 9

A number of efforts are underway to better understand the role of genetic variation in successful aging and longevity. However, to date, only two genes have been consistently associated with longevity in humans: APOE and FOXO3, with the APOE ɛ2 allele also protective against dementia. Recently, using an exome-wide SNP array approach, a missense variant CLEC3B c.316G>A (rs13963 p.S106G) was reported to associate with longevity in two independent cohorts of Japanese and Chinese participants. Inter ...[more]

PMID: 31570938

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Project description:AIM:The aim of this study was to quantify gender-specific facial characteristics in younger and older adults and to determine how aging and body characteristics, such as height and body-mass index (BMI), influence facial sexual dimorphism. METHODS:The cohort study included 90 younger adults of Caucasian origin (average age of 45 females 23.2 ± 1.9 and 45 males 23.7 ± 2.4 years) and 90 older adults (average age of 49 females 78.1 ± 8.1 and 41 males 74.5 ± 7.7 years). Three-dimensional facial scans were performed with an Artec MHT 3D scanner. The data were analyzed using the software package Rapidform®. The parameters to evaluate facial symmetry, height, width, profile, facial shape, nose, eyes and mouth characteristics were determined based on 39 facial landmarks. Student's t-test was used to calculate the statistical differences between the genders in the younger and older adults and a multiple-linear-regression analysis was used to evaluate the impact of gender, age, body-mass index and body height. RESULTS:We found that the female faces were more symmetrical than the male faces, and this was statistically significant in the older adults. The female facial shape was more rounded and their faces were smaller, after normalizing for body size. The males had wider mouths, longer upper lips, larger noses and more prominent lower foreheads. Surprisingly, we found that all the gender-dependent characteristics were even more pronounced in the older adults. Increased facial asymmetry, decreased facial convexity, increased forehead angle, narrower vermilions and longer inter-eye distances occurred in both genders during aging. An increased BMI was associated with wider faces, more concave facial profiles and wider noses, while greater body height correlated with increased facial heights and wider mouths. CONCLUSION:Facial sexual dimorphism was confirmed by multiple parameters in our study, while the differences between the genders were more pronounced in the older adults.

Dataset Information

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.

Publications

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.

Similar Datasets

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