Longitudinal Association Between Energy Regulation and Fatigability in Mid-to-Late Life.

ABSTRACT:

Background

Deficits in energy production and utilization have been linked to higher fatigue and functional decline with aging. Lesser known is whether individuals with a combination of low peak energy capacity and high energy costs for mobility (eg, impaired energy regulation) are more likely to experience the onset and progression of high fatigability with aging.

Methods

Participants in the Baltimore Longitudinal Study of Aging (n = 651, 49.0% male, mean age 71.9, range 50-94) with ≥2 visits who completed fatigability (Borg rating of perceived exertion [RPE] after a 5-minute 1.5 mph treadmill walk), slow walking energy expenditure (VO2 mL/kg/min), and peak walking energy expenditure (VO2 mL/kg/min), testing between 2007 and 2018. The longitudinal association between each me

SUBMITTER: Schrack JA 

PROVIDER: S-EPMC7494036 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature