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NAD+ in Aging: Molecular Mechanisms and Translational Implications.

ABSTRACT: The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD+ levels is important for cells with high energy demands and for proficient neuronal function. NAD+ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atrophy. Emerging evidence suggests that NAD+ decrements occur in various tissues during aging, and that physiological and pharmacological interventions bolstering cellular NAD+ levels might retard aspects of aging and forestall some age-related diseases. Here, we discuss aspects of NAD+ biosynthesis, together with putative mechanisms of NAD+ action against aging, including recent preclinical and clinical trials.

SUBMITTER: Fang EF

PROVIDER: S-EPMC7494058 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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NAD+ in Aging: Molecular Mechanisms and Translational Implications.

Fang Evandro F EF Lautrup Sofie S Hou Yujun Y Demarest Tyler G TG Croteau Deborah L DL Mattson Mark P MP Bohr Vilhelm A VA

Trends in molecular medicine 20170909 10

The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD+ levels is important for cells with high energy demands and for proficient neuronal function. NAD+ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atroph ...[more]

PMID: 28899755

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