Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine.

ABSTRACT:

Background

Rodent cardiomyocytes (CM) undergo mitotic arrest and decline of mononucleated-diploid population post-birth, which are implicated in neonatal loss of heart regenerative potential. However, the dynamics of postnatal CM maturation are largely unknown in swine, despite a similar neonatal cardiac regenerative capacity as rodents. Here, we provide a comprehensive analysis of postnatal cardiac maturation in swine, including CM cell cycling, multinucleation and hypertrophic growth, as well as non-CM cardiac factors such as extracellular matrix (ECM), immune cells, capillaries, and neurons. Our study reveals discordance in postnatal pig heart maturational events compared to rodents.

Methods and results

Left-ventricular myocardium from White Yorkshire-Landrace pigs at pos

SUBMITTER: Velayutham N 

PROVIDER: S-EPMC7494622 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature