Toxicity and cosmetic outcomes after treatment with a novel form of breast IORT.

ABSTRACT:

Purpose

Intraoperative radiation therapy (IORT), a form of accelerated partial breast irradiation (APBI), is an appealing alternative to postoperative whole breast irradiation for early-stage breast cancer. The purpose of this study was to examine the toxicity and cosmetic outcomes of patients treated with a novel form of breast IORT (precision breast IORT; PB-IORT), that delivers a targeted, higher dose of radiation than conventional IORT.

Methods and materials

The first 204 patients treated with PB-IORT in a Phase II clinical trial (NCT02400658) with 12 months of followup were included. Trial inclusion criteria were age ≥45 years, invasive or in situ breast cancer, tumor size ≤3 cm, and node negative. Toxicity and cosmetic scoring were performed at 6 and 12 months.

Resu

SUBMITTER: Meneveau MO 

PROVIDER: S-EPMC7494626 | biostudies-literature | 2020 Sep - Oct

REPOSITORIES: biostudies-literature