Ontology highlight
ABSTRACT:
SUBMITTER: Barre R
PROVIDER: S-EPMC7494670 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Barre Ronan R Beton Nicolas N Batut Aurélie A Accabled Frank F Sales de Gauzy Jerome J Auriol Françoise F Eddiry Sanaa S Tauber Maithe M Laurencin Sara S Salles Jean Pierre JP Gennero Isabelle I
Biochemistry and biophysics reports 20200911
We have examined the Acylated Ghrelin (AG)/Gi pathway in different human osteoblastic cell lines. We have found that: 1) AG induces differentiation/mineralization only in mature osteoblasts; 2) the expression of GHS-R1a increases up to the mature cell stage, 3) the action is mediated via the GHS-R/Gi/cAMP pathway only in mature osteoblasts, and 4) osteoblastic cells from adolescent idiopathic scoliosis (AIS) are resistant to the AG/Gi/cAMP pathway. Altogether, these results suggested that AG use ...[more]