Ontology highlight
ABSTRACT:
SUBMITTER: Danielyan L
PROVIDER: S-EPMC7494685 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Danielyan Lusine L Schwab Matthias M Siegel Georg G Brawek Bianca B Garaschuk Olga O Asavapanumas Nithi N Buadze Marine M Lourhmati Ali A Wendel Hans-Peter HP Avci-Adali Meltem M Krueger Marcel A MA Calaminus Carsten C Naumann Ulrike U Winter Stefan S Schaeffeler Elke E Spogis Annett A Beer-Hammer Sandra S Neher Jonas J JJ Spohn Gabriele G Kretschmer Anja A Krämer-Albers Eva-Maria EM Barth Kerstin K Lee Hong Jun HJ Kim Seung U SU Frey William H WH Claussen Claus D CD Hermann Dirk M DM Doeppner Thorsten R TR Seifried Erhard E Gleiter Christoph H CH Northoff Hinnak H Schäfer Richard R
EBioMedicine 20200910
<h4>Background</h4>Stem cells` (SC) functional heterogeneity and its poorly understood aetiology impedes clinical development of cell-based therapies in regenerative medicine and oncology. Recent studies suggest a strong correlation between the SC migration potential and their therapeutic efficacy in humans. Designating SC migration as a denominator of functional SC heterogeneity, we sought to identify highly migrating subpopulations within different SC classes and evaluate their therapeutic pro ...[more]