Ontology highlight
ABSTRACT:
SUBMITTER: Forsberg BO
PROVIDER: S-EPMC7494870 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Forsberg B O BO Aibara S S Howard R J RJ Mortezaei N N Lindahl E E
Nature communications 20200916 1
The pyruvate dehydrogenase complex (PDC) is a multienzyme complex central to aerobic respiration, connecting glycolysis to mitochondrial oxidation of pyruvate. Similar to the E3-binding protein (E3BP) of mammalian PDC, PX selectively recruits E3 to the fungal PDC, but its divergent sequence suggests a distinct structural mechanism. Here, we report reconstructions of PDC from the filamentous fungus Neurospora crassa by cryo-electron microscopy, where we find protein X (PX) interior to the PDC cor ...[more]