Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC7494942 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wang Jianguo J Jiang Qiang Q Faleti Oluwasijibomi Damola OD Tsang Chi-Man CM Zhao Min M Wu Gongfa G Tsao Sai-Wah SW Fu Minyi M Chen Yuxiang Y Ding Tengteng T Chong Tuotuo T Long Yufei Y Yang Xu X Zhang Yuanbin Y Cai Yunxi Y Li Hanzhao H Peng Manli M Lyu Xiaoming X Li Xin X
Molecular therapy. Nucleic acids 20200819
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated cancer characterized by a high degree of recurrence, angiogenesis, and metastasis. The importance of alternative pro-angiogenesis pathways including viral factors has emerged after decades of directly targeting various signaling components. Using NPC as a model, we identified an essential oncogenic pathway underlying angiogenesis regulation that involves the inhibition of a tumor suppressor, Spry3, and its downstream target ...[more]