Differential effects of antidepressant subgroups on risk of acute myocardial infarction: A nested case-control study.

ABSTRACT: The primary objective of this study was to investigate the association between antidepressants use and the risk of acute myocardial infarction (AMI).

Methods

We conducted a nested case-control study using a primary care database over the period 2002-2015. From a cohort of patients aged 40-99 years, we identified incident AMI cases and randomly selected 5 controls per case, matched to cases for exact age, sex and index date. Exposure to antidepressants were categorised as current, recent, past and nonusers. Adjusted odds ratio (AOR) and 95% confidence interval (CI) were computed using conditional logistic regression to assess the association between the current use of different antidepressants subgroups and AMI as compared to nonuse. Dose and duration effects were explored.

Result

SUBMITTER: Alqdwah-Fattouh R 

PROVIDER: S-EPMC7495291 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature