Ontology highlight
ABSTRACT:
SUBMITTER: Newton H
PROVIDER: S-EPMC7495438 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Newton Holly H Wang Yi-Fang YF Camplese Laura L Mokochinski Joao B JB Kramer Holger B HB Brown André E X AEX Fets Louise L Hirabayashi Susumu S
Nature communications 20200916 1
Cancer cells demand excess nutrients to support their proliferation, but how tumours exploit extracellular amino acids during systemic metabolic perturbations remain incompletely understood. Here, we use a Drosophila model of high-sugar diet (HSD)-enhanced tumourigenesis to uncover a systemic host-tumour metabolic circuit that supports tumour growth. We demonstrate coordinate induction of systemic muscle wasting with tumour-autonomous Yorkie-mediated SLC36-family amino acid transporter expressio ...[more]