Ontology highlight
ABSTRACT:
SUBMITTER: Huang D
PROVIDER: S-EPMC7495923 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Huang David D Szewczyk Suzanne M SM Zhang Pengpeng P Newhouse Timothy R TR
Journal of the American Chemical Society 20190325 14
We herein disclose the first report of a first-row transition metal-catalyzed α,β-dehydrogenation of carbonyl compounds using allyl-nickel catalysis. This development overcomes several limitations of previously reported allyl-palladium-catalyzed oxidation, and is further leveraged for the development of an oxidative cycloalkenylation reaction that provides access to bicycloalkenones with fused, bridged, and spirocyclic ring systems using unactivated ketone and alkene precursors. ...[more]