Estrogen receptor-beta genetic variations and overall survival in patients with locally advanced gastric cancer.
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ABSTRACT:
SUBMITTER: Sunakawa Y
PROVIDER: S-EPMC7496219 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Estrogen receptor-beta genetic variations and overall survival in patients with locally advanced gastric cancer.
Sunakawa Y Y Cao S S Berger M D MD Matsusaka S S Yang D D Zhang W W Ning Y Y Parekh A A Stremitzer S S Mendez A A Okazaki S S Wakatsuki T T Azuma M M Shimada K K Watanabe M M Koizumi W W Wu A H AH Lenz H-J HJ
The pharmacogenomics journal 20151027 1
Estrogen has been shown not only to reduce the incidence of colorectal cancer but also gastric cancer (GC). Polymorphisms in estrogen receptor β gene, ESR2, correlate with colorectal cancer survival. To better understand the role of ESR2 in GC, genomic DNA extracted from 169 Japanese patients and 172 patients from Los Angeles County (LAC) was analyzed for association of overall survival (OS) with three ESR2 polymorphisms, which are of biological significance using multivariable Cox proportional ...[more]
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