Ontology highlight
ABSTRACT:
SUBMITTER: Korschgen H
PROVIDER: S-EPMC7496240 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Körschgen Hagen H Jäger Christian C Tan Kathrin K Buchholz Mirko M Stöcker Walter W Ramsbeck Daniel D
ChemMedChem 20200702 16
Despite huge progress in hormonal therapy and improved in vitro fertilization methods, the success rates in infertility treatment are still limited. A recently discovered mechanism revealed the interplay between the plasma protein fetuin-B and the cortical granule-based proteinase ovastacin to be a novel key mechanism in the regulation of fertilization. Upon sperm-egg fusion, cleavage of a distinct zona pellucida component by ovastacin destroys the sperm receptor, enhances zona robustness, and e ...[more]